Andrew Huberman, a Professor of Neurobiology and Ophthalmology at Stanford University, and host of the "Huberman Lab"Podcast. Went on a few podcasts including The Joe Rogan Experience, and The Tim Ferriss Show talking about Testosterone Optimization, sleep and performance.
He speaks in detail about two specific ingredients fadogia agrestis and tongkat ali, and how they "work very well to increase testosterone by about 100 to200 points". This is no small claim by any means and results of course vary per individual.
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Andrew Huberman expanded on the benefits of a natural testosterone booster for men saying, "People who aren't getting prescribed TRT but want to experience the increase in testosterone that it offers can take advantage of Tongkat Ali supplements and Fadogia Agrestis supplements. These plant compounds like Tongkat Ali and Fadogia Agrestis can be very interesting. There is a Nigerian shrub called fadogia agrestis and it mimics the human luteinizing hormone which is the hormone that comes out of the hypothalamus that stimulates the testes if you got those and your ovaries if you've got those to make more testosterone or estrogen and so those two herbal supplements together can give a significant boost in free and active testosterone.”
Andrew Huberman expanded on the benefits of a natural testosterone booster for men saying, "People who aren't getting prescribed TRT but want to experience the increase in testosterone that it offers can take advantage of Tongkat Ali supplements and Fadogia Agrestis supplements. These plant compounds like Tongkat Ali and Fadogia Agrestis can be very interesting. There is a Nigerian shrub called fadogia agrestis and it mimics the human luteinizing hormone which is the hormone that comes out of the hypothalamus that stimulates the testes if you got those and your ovaries if you've got those to make more testosterone or estrogen and so those two herbal supplements together can give a significant boost in free and active testosterone.”
Joe Rogan; "So you said Tongkat Ali can give you 100 to 200 - what does the other one give you?"
Andrew Huberman; "Fadogia ... the most dramatic effect I’ve ever seen was somebody you had is testosterone down in the low twos or I think it was like low twos (200s) and he got it up to the 700 range which but that's it but that's an outlier, right. Most people are gonna see about a three (300) to four (400) hundred point increase"
Joe Rogan; "and that's what the two of them synergistically"
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Andrew: The hormone augmentation thing is always a little bit of a complicated discussion but there's so much that’s happening there right now that's really interesting.
Joe: Like what?
Andrew: Well for instance, um, sort of back to the topic of supplements I always say look their behaviors are the fundamental layer you have to do the right things for anything for sleep for learning for sports performance but then there are nutrition supplementation prescription drugs and then off-label stuff right and so we always think about when you hear hormones in sports you always Think just the raw conversation about anabolics all the band stuff we can talk about that stuff and how it works years ago I used to work on androgens testosterone and its derivatives and how it impacts brain development and body function fear and also mental states but there's a category of supplements that are very interesting that for most people who aren't exploring testosterone augmentation for a sport that works very well to increase testosterone by about 100 to 200 points not you know 300 you know not a tripling or anything like that and the main ones are two substances one is called Tongkat Ali.
Joe: Oh yeah that stuff's real huh??
Andrew: Yeah! Oh yeah! Because what happens is the testosterone molecule it’s basically carried in cargo so it can be in its free form unbound form free testosterone and everyone says oh I want more free testosterone you want more but the these what are called sex hormone binding globulins so there's something called sex hormone binding globulin and albumin they carry the testosterone molecule to the different tissues of the body so you don't want all your testosterone free you want some of it bound up so that it can be delivered to the different tissues including your brain but if you have too much sex hormone bonding globulin the testosterone can't really do its things okay so Tongkat Ali about 400 milligrams per day has the effect of raising free testosterone and overall testosterone by about 100 to 200 points
05:23:
Andrew: Now for people that aren't getting prescribed trt but want the increase in testosterone there are these plant compounds like Tongkat Ali and another one which is very interesting it's a Nigerian shrub called fadogia agrestis and it mimics luteinizing hormone which is the hormone that comes out of the hypothalamus that stimulates the testes if you got those and your ovaries if you've got those to make more Testosterone or estrogen and so those two herbal supplements together can give a significant boost in free and active testosterone
Joe: So, you said Tongkat Ali can give you 100 to 200
Andrew: Yeah, about that
Joe: What does the other one give you?
Andrew: Fadoja is usually taken at about 600 milligrams… the most dramatic effect I’ve ever seen was somebody you had is testosterone down in the low twos or I think it was like low twos and he got it up to the 700 range which but that's it but that's an outlier right most people are gonna see about a three to four hundred point increase.
Joe: And that's what the 2 of them synergistically?
Andrew: Yeah, the fadogia will actually make the testes grow.
6:26:
Andrew: Well, the reason I know about this stuff. People are probably thinking like you know Huberman’s running gear out of the back of his cars and that's not what this is about is that I do a certain amount of work with the military, and I do a certain amount of work with professional athletes who cannot take androgen compounds out of a syringe because they'll lose their job. Or they've been doing that, and they want to come off.
07:17:
Andrew: Testosterone has the effects we're all aware of like deepening the voice facial hair muscle growth recovery etc. mostly because testosterone increases protein synthesis you look at a young male in puberty it's a protein synthesis machine yeah they eat, they eat and they just grow and grow and grow and they're putting on muscles and they're lean and you know so most often they're lean but in any case, testosterone has some very interesting effects on the brain the major mental effect of testosterone is it makes effort feel good.
Joe: Oh, that makes sense
Andrew: And the reason it does it is that the amygdala this fear center in the brain this anxiety center in the brain has androgen receptors it has testosterone receptors… so, when humans are taking low doses or reasonable doses of testosterone or they're increasing their testosterone or they're going through puberty effort and leaning into pain and challenge actually has the effect of making the body feel soothed and good it's a drive just like sex is a drive or drinking water when you're thirsty as a Drive this stuff is all anchored deep within the hypothalamus this isn't a cognitive thing.
Joe: That makes sense why young men, in particular, are really driven to hard exercise and sports that are very very difficult that requires extreme effort completely makes sense.
Andrew: Yeah, and why when people are testosterone depleted, they feel depressed and when people have a surge of testosterone, they feel relief and anxiety. Provided it's in the appropriate range.
If you'd like to listen to the podcast here are some links for you.
Full Podcast: The Joe Rogan Experience
Youtube Clip: Andrew Huberman Talks About Testosterone Optimization
Science and Studies Behind Elevated:
